Any queries (other than missing content) should be directed to the corresponding author for the article.ADepartment of Urology, Guangdong Key Laboratory of Clinical Molecular Medicine and Diagnostics, Guangzhou First PeopleвЂ™s Hospital, School of Medicine, South China University of Technology, Guangzhou, ChinaД«Laboratory Animal Center, Guangzhou Medical University, Guangzhou, ChinaД¬Guangzhou HYY Precision&Translation Medicine Institute, Guangzhou, ChinaДDepartment of Urology, Hwa Mei Hospital, University of Chinese Academy of Sciences, Ningbo, China Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Effect of RAASi treatment on blood pressure levels in RHD participants at the end of follow-up.

Effect of RAASi and Surgical treatment on heart remodeling in RHD participants at the end of follow-up. Effect of RAASi treatment on heart remodeling in RHD participants at the end of follow-up. cModel 4s: It is the same as Model 2s with exception of those covariates, including: LVD, RVD, and RAD. bModel 3s: It is the same as Model 2s with exception of those covariates, including: new-onset AF, LVD, RVD, and RAD. aModel 2s: It is the same as Model S2, and also including new-onset AF. Effect of RAASi on the risks of HF rehospitalization a, new-onset AF b and new-onset stroke c. Causes of death among study participants before PSM. ReninвЂ“angiotensinвЂ“aldosterone system inhibitor treatment was significantly associated with decreased risks of mortality, HF rehospitalization, and new-onset AF in RHD patients in median 5.9В year follow-up.Д®hf21362-Supplementary Material-revised(clean copy).docxWord 2007 documentДЇigure S1.

RAASi treatment had nothing to do with new-onset stroke risk (adjusted ORВ =В 0.80, 95% CI: 0.47вЂ“1.38, PВ =В 0.428). After propensity score matching, 514 RHD patients were finally analysed. A total of 734 RHD patients were enrolled as study participants nearly half of these participants had combined valve damage (54.4%), worse New York Heart Association functional class status (III and IV, 55.2%), surgical treatment (54.2%), and AF (65.0%). Binary logistic regression analysis was used to evaluate the associations of RAASi with the risks of 1, 3, and 5В year heart failure (HF) rehospitalization, new-onset atrial fibrillation (AF), and new-onset stroke. Cox proportional hazards regression model was used to investigate the associations of RAASi with the risks of all-cause mortality, cardiovascular death (CVD), and cerebrovascular death. Methods and resultsДЄ 1:1 propensity score matching was implemented to balance baseline characteristics between groups RAASi and non-RAASi. We performed a retrospective study to determine the effect of RAASi on long-term outcomes for RHD patients. ReninвЂ“angiotensinвЂ“aldosterone system inhibitors (RAASi) are commonly administered in the treatment of cardiovascular disease, but its role in RHD patients is still limited. Rheumatic heart disease (RHD) remains a major global health problem.

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